What is SRT-2104?
SRT-2104 is a synthetic small molecule originally developed by Sirtris Pharmaceuticals (acquired by GSK) as a potent activator of SIRT1, a key longevity-related enzyme in the sirtuin family. SIRT1 is involved in regulating metabolism, inflammation, mitochondrial function, and cellular survival—making it a major target in anti-aging and metabolic research.
Scientific Background
- SIRT1 is a NAD⁺-dependent deacetylase associated with enhanced mitochondrial biogenesis, improved metabolic flexibility, and anti-inflammatory effects.
- SRT-2104 has been shown to activate SIRT1 in vitro and in vivo, mimicking some of the benefits of caloric restriction.
- Clinical trials and animal studies suggest potential in improving insulin sensitivity, vascular function, bone density, and inflammatory modulation.
Key Research Highlights
- In a Phase 1 human trial, SRT-2104 was well tolerated and showed biological activity relevant to lipid metabolism and inflammation.
📖 Timmers S et al., 2011. British Journal of Clinical Pharmacology.
PubMed: 21838795 - In animal studies, SRT-2104 extended median lifespan in mice on a high-fat diet and improved mitochondrial markers.
📖 Mitchell SJ et al., 2014. Cell Reports.
PubMed: 25199830
Potential Applications
- 🔬 Anti-aging and longevity protocols
- 🧠 Neuroprotective therapies
- 🩸 Cardiometabolic regulation
- 🦴 Bone and musculoskeletal health
- 🔋 Energy, fatigue, and mitochondrial support
SRT-2104 may be useful for clients seeking NAD⁺ alternatives or adjuncts, or clinics developing sirtuin-based longevity programs.
BLUEBIOTECH’s SRT-2104 (RUO Grade)
- Purity ≥ 98% (HPLC-tested)
- Supplied in sealed amber glass vials
- Available in 10mg / 50mg / 100mg formats
- RUO grade: For research use only, not for human consumption
- Optional OEM/white label for qualified clinics or researchers
Learn More or Request a Quote
SRT-2104 is available to qualified buyers and researchers under our RUO supply program. Contact BLUEBIOTECH to request pricing, datasheet, or COA.
📎 Scientific References
- PubMed: 21838795 – Human Pharmacokinetics
- PubMed: 25199830 – Lifespan & Mitochondria
- ClinicalTrials.gov – SRT2104 Studies
⚠️ Disclaimer
This compound is provided strictly for laboratory research use. It is not approved by the FDA for any medical use, and it is not intended to diagnose, treat, or cure any disease.
