Adipotide (FTPP)

Adipotide (FTPP) | Targeted Proapoptotic Peptide for Obesity & Adipose Reduction Research

Category: Peptides → Obesity / Fat-Targeting Therapy / Apoptosis Research
Synonyms: FTPP, Prohibitin-targeting peptide, Fat-targeted pro-apoptotic peptide
Sequence: CKGGRAKDC-GG-D(KLAKLAK)₂
Molecular Formula: C70H130N26O16S2 (approximate, varies by form)
Purity: ≥99% (HPLC)

Scientific Overview

Adipotide (FTPP) is an experimental proapoptotic peptide designed to selectively target white adipose tissue (WAT) vasculature, triggering apoptosis in blood vessels feeding fat cells, leading to fat mass reduction and weight loss. It operates through a two-domain structure:

• A homing domain(CKGGRAKDC) that binds to prohibitin receptors on adipose endothelial cells
• A pro-apoptotic domain(D(KLAKLAK)₂) that disrupts mitochondrial membranes once internalized

Preclinical studies in obese rodent and primate models have shown that Adipotide leads to rapid loss of subcutaneous and visceral fat, with improvements in insulin sensitivity, lipid metabolism, and hepatic steatosis.

Key Research Applications

• Selective adipose tissue ablation and fat metabolism research
• Novel anti-obesity mechanism exploration (non-GLP-1 pathway)
• Vascular-targeted peptide therapy and angiogenesis modulation
• Mitochondrial disruption and cell-specific apoptosis studies
• Insulin resistance and glucose homeostasis modeling
• Comparison with GLP-1/Tirzepatide/Mazdutide research models

Highlighted Research Publications

1. Mechanism of Fat Cell Apoptosis via Vascular Targeting
   Adipotide targets WAT vasculature and induces apoptosis leading to fat reduction
   Science Translational Medicine, 2012
2. Efficacy in Nonhuman Primates
   Treatment led to significant weight loss and improved metabolic markers in obese rhesus monkeys
   Science Translational Medicine, 2012
3. Prohibitin as a Vascular Target in Fat
   Homing peptide binds prohibitin, expressed selectively on adipose endothelium
   Nature Medicine, 2004
4. Metabolic Benefits Beyond Weight Loss
   Improves insulin sensitivity and reduces hepatic lipid accumulation
   Endocrinology, 2013

Product Format & Notes

• Form:White lyophilized peptide powder
• Solubility:Soluble in sterile water or DMSO
• Storage:–20°C, protected from light and moisture
• Recommended Use:Obesity models, angiogenesis studies, fat metabolism & apoptosis research

For Research Use Only

This product is intended strictly for scientific and laboratory research use. It is not for human consumption, medical use, or diagnostic applications. Please use in accordance with local regulations and institutional guidelines.