ARA 290 / Cibinetide

ARA 290 | Selective Innate Repair Receptor Agonist for Inflammation & Neuroregeneration Research

Category: Peptides → Neuroprotection / Anti-Inflammatory / Diabetic Neuropathy
Synonyms: Cibinetide, HBSP (Helix B Surface Peptide), EPO-Derived Peptide
Sequence: Pyr-Glu-Glu-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-Leu-Ala-Leu-Arg
Molecular Formula: C66H106N18O20
Purity: ≥99% (HPLC)

Scientific Overview

ARA 290, also known as Cibinetide, is a non-erythropoietic peptide derived from the B-helix of erythropoietin (EPO). It specifically activates the Innate Repair Receptor (IRR) — a heterodimer composed of EPOR and CD131 — triggering tissue-protective, anti-inflammatory, and neuroregenerative pathways, without stimulating red blood cell production.

ARA 290 has shown promise in a wide range of preclinical and clinical research contexts including diabetic peripheral neuropathy (DPN), small fiber neuropathy, ischemic tissue damage, and autoimmune disorders. It is being explored for its ability to modulate cytokine signaling, reduce oxidative stress, and preserve organ and neuronal function.

Key Research Applications

• Diabetic peripheral neuropathy and small fiber neuropathy models
• Tissue ischemia and ischemia-reperfusion injury
• Autoimmune inflammation (e.g., sarcoidosis, lupus)
• Endothelial protection and microvascular integrity studies
• Non-hematopoietic EPO receptor signaling research
• Chronic pain and neuroinflammatory conditions

Highlighted Research Publications

1. Treatment of Small Fiber Neuropathy in Diabetic Patients
   ARA 290 improved symptoms and intraepidermal nerve fiber density
   Molecular Pain, 2012
2. Innate Repair Receptor Activation Mechanism
   Selective targeting of the EPOR-CD131 complex promotes anti-inflammatory repair
   American Journal of Pathology, 2011
3. Tissue Protection Without Erythropoiesis
   ARA 290 decouples the cytoprotective and hematopoietic effects of EPO
   Journal of Translational Medicine, 2008
4. Application in Sarcoidosis and Chronic Inflammation
   Cibinetide reduced inflammatory biomarkers and improved quality of life in sarcoidosis patients
   Cytokine, 2016

Product Format & Notes

• Form:White lyophilized peptide powder
• Solubility:Soluble in water, PBS, or mild acid buffer
• Storage:–20°C, protect from light and moisture
• Recommended Use:Chronic inflammation, neurodegeneration, tissue repair research

For Research Use Only

This product is supplied exclusively for laboratory and scientific research. It is not intended for human use, therapeutic application, or diagnostic procedures. Please ensure compliance with institutional and national guidelines.