FOXO4-DRI – Cell-Permeable Senolytic Peptide | 10mg
FOXO4-DRI – Cell-Permeable Senolytic Peptide | 10mg Lyophilized Powder | RUO Grade | BlueBiotech® Research Supply
Targeted Peptide for Selective Senescent Cell Apoptosis via p53 Pathway Disruption | Made in USA | Research Use Only
FOXO4-DRI (FOXO4-DRI Peptide) is a designed cell-penetrating peptide that selectively induces apoptosis in senescent cells by interfering with the interaction between FOXO4 and p53. This makes it a unique and powerful tool for studying aging, tissue regeneration, and longevity enhancement. Supplied as 10mg RUO-grade lyophilized powder. For Research Use Only – Not for human or veterinary use.
| Field Name | Example Value |
|---|---|
| Product Name | FOXO4-DRI – Cell-Permeable Senolytic Peptide | 10mg Lyophilized Powder | RUO Grade | BlueBiotech® Research Supply |
| Product Code | BBT-US-30-699792 |
| Product Type | Research Peptide |
| Category | Peptides / Senescence Research / Apoptosis Modulators / Anti-Aging |
| Manufacturer | BlueBiotech® Research Facility |
| Appearance | White lyophilized powder |
| Dosage / Units | 10mg per vial |
| Purity | ≥99% (HPLC) |
| Quantity Options | 5mg / 10mg |
| Storage | Store at -20°C; avoid exposure to moisture and light |
| Shelf Life | 24 months unopened |
| Packaging | RUO-labeled sterile 10R vial, foil pouch |
| Manufacturer Origin | USA – Made in USA |
| Use Classification | RUO – Research Use Only (Not intended for human or veterinary use) |
| Tags | FOXO4-DRI, senolytic peptide, p53 disruptor, aging research, cell apoptosis, BlueBiotech, RUO, made in USA, 10mg anti-aging peptide |
⚠️This product is labeled for Research Use Only (RUO). Not for human or veterinary therapeutic use.
See RUO Declaration for more info.
FOXO4-DRI Peptide | Senolytic Research Tool Targeting Cellular Senescence
Category: Peptides → Senescence / Apoptosis / Anti-Aging
Synonyms: FOXO4 D-Retro-Inverso Peptide, FOXO4-DRI
Molecular Formula: C106H175N31O29
Sequence (D-Retro-Inverso): Ac-D-Arg-D-Tyr-D-Lys-D-Gln-D-Asn-D-Ser-D-Glu-D-Tyr-D-Gln-D-Arg-D-Gln-D-Glu-D-Ser-D-Arg-D-Lys-D-Lys-D-Tyr-D-Glu-D-Glu-D-Glu-NH₂
Purity: ≥99% (HPLC)
Scientific Overview
FOXO4-DRI is a synthetic D-retro-inverso peptide designed to disrupt the interaction between FOXO4 (Forkhead Box O4) and p53, a key complex that maintains senescent cell viability. This disruption selectively induces apoptosis in senescent cells (senolysis) without harming normal proliferating or quiescent cells.
FOXO4-DRI has been a groundbreaking tool in aging research for its potential to rejuvenate tissues, improve organ function, and reverse physical dysfunction in aged animal models. It is also under investigation in fibrosis, neurodegenerative diseases, and age-related cancer biology.
Key Research Applications
- Selective clearance of senescent cells (senolysis)
- DNA damage and p53-mediated stress response models
- Tissue regeneration and anti-aging intervention studies
- Organ function recovery in age-related disease models
- Tumor microenvironment and immune evasion research
- Studies on FOXO transcription factors in aging and apoptosis
Highlighted Research Publications
- Landmark Study in Senolysis
FOXO4-DRI selectively induces apoptosis in senescent cells, restoring tissue homeostasis
Cell, 2017
➤Showed functional recovery of kidney and liver in aged mice - p53 Pathway Disruption Mechanism
FOXO4-p53 interaction stabilizes senescence; FOXO4-DRI disrupts this axis
Aging Cell, 2018 - Senescent Cell Clearance and Lifespan Implications
Senolytics including FOXO4-DRI extend healthspan and reduce inflammation
Nature Reviews Molecular Cell Biology, 2020
Product Format & Notes
- Form:Lyophilized peptide powder
- Solubility:Soluble in DMSO or acetic acid; dilute with sterile PBS before use
- Storage:–20°C, desiccated, light-protected
- Recommended Use:In vitro senescence assays, aged tissue models, p53 pathway studies
For Research Use Only
This compound is supplied strictly for scientific and laboratory research. It is not for use in humans, therapeutic purposes, or diagnostic procedures. Use in compliance with applicable institutional and national regulations is required.
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⚠️ All compounds are provided strictly for Research Use Only (RUO). BLUEBIOTECH does not endorse or support clinical, therapeutic, or diagnostic use of its products unless under licensed compounder supervision.