FOXO4-DRI

FOXO4-DRI Peptide | Senolytic Research Tool Targeting Cellular Senescence

Category: Peptides → Senescence / Apoptosis / Anti-Aging
Synonyms: FOXO4 D-Retro-Inverso Peptide, FOXO4-DRI
Molecular Formula: C106H175N31O29
Sequence (D-Retro-Inverso): Ac-D-Arg-D-Tyr-D-Lys-D-Gln-D-Asn-D-Ser-D-Glu-D-Tyr-D-Gln-D-Arg-D-Gln-D-Glu-D-Ser-D-Arg-D-Lys-D-Lys-D-Tyr-D-Glu-D-Glu-D-Glu-NH₂
Purity: ≥99% (HPLC)

Scientific Overview

FOXO4-DRI is a synthetic D-retro-inverso peptide designed to disrupt the interaction between FOXO4 (Forkhead Box O4) and p53, a key complex that maintains senescent cell viability. This disruption selectively induces apoptosis in senescent cells (senolysis) without harming normal proliferating or quiescent cells.

FOXO4-DRI has been a groundbreaking tool in aging research for its potential to rejuvenate tissues, improve organ function, and reverse physical dysfunction in aged animal models. It is also under investigation in fibrosis, neurodegenerative diseases, and age-related cancer biology.

Key Research Applications

• Selective clearance of senescent cells (senolysis)
• DNA damage and p53-mediated stress response models
• Tissue regeneration and anti-aging intervention studies
• Organ function recovery in age-related disease models
• Tumor microenvironment and immune evasion research
• Studies on FOXO transcription factors in aging and apoptosis

Highlighted Research Publications

1. Landmark Study in Senolysis
   FOXO4-DRI selectively induces apoptosis in senescent cells, restoring tissue homeostasis
   Cell, 2017
   ➤Showed functional recovery of kidney and liver in aged mice
2. p53 Pathway Disruption Mechanism
   FOXO4-p53 interaction stabilizes senescence; FOXO4-DRI disrupts this axis
   Aging Cell, 2018
3. Senescent Cell Clearance and Lifespan Implications
   Senolytics including FOXO4-DRI extend healthspan and reduce inflammation
   Nature Reviews Molecular Cell Biology, 2020

Product Format & Notes

• Form:Lyophilized peptide powder
• Solubility:Soluble in DMSO or acetic acid; dilute with sterile PBS before use
• Storage:–20°C, desiccated, light-protected
• Recommended Use:In vitro senescence assays, aged tissue models, p53 pathway studies

For Research Use Only

This compound is supplied strictly for scientific and laboratory research. It is not for use in humans, therapeutic purposes, or diagnostic procedures. Use in compliance with applicable institutional and national regulations is required.