GDF-8（Myostatin）

GDF-8 (Myostatin) | Key Myostatin Pathway Protein for Muscle Regulation & Atrophy Research

Category: Growth Factors → Muscle Inhibition / Aging / Cachexia
Keyphrase: GDF-8 peptide
Purity: ≥99% (HPLC)

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🧬 Understanding GDF-8 and Its Role in Muscle Physiology

GDF-8, more commonly known as Myostatin, is a critical signaling protein that negatively regulates muscle mass. As a member of the TGF-β superfamily, it functions by inhibiting myoblast proliferation, thereby restricting excessive muscle growth. GDF-8 is primarily expressed in skeletal muscle tissue and serves as a molecular brake in muscle homeostasis.

Inhibition of this pathway is of great interest in studies targeting sarcopenia, muscle wasting diseases, and age-related muscle loss.

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📌 Product Specifications

• Synonyms: Growth Differentiation Factor 8, Myostatin

• Sequence Type: Full-length recombinant protein or synthetic peptide analogs

• Molecular Weight: ~25 kDa (active dimer)

• Molecular Formula: Protein form varies; peptide analogs available

• Form: Lyophilized powder or solution

• Purity: ≥99% (HPLC or SDS-PAGE standard)

• Keyphrase: GDF-8 peptide

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🧪 Scientific Applications in Myostatin Inhibition Research

The GDF-8 signaling pathway is widely explored for its role in:

• Inducing muscle atrophy in disuse, aging, and cancer-related models

• Serving as a reference protein in myostatin inhibition studies

• Enabling research into gene editing, antibody therapy, and decoy receptor development

• Supporting comparative studies with Follistatin, ACE-031, and IGF-1 LR3

When inhibited, GDF-8 can lead to muscle hypertrophy, making it a potent target in both regenerative and performance enhancement research.

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📚 Research Highlights & Citations

1. Myostatin Discovery and Function
   GDF-8 knockout mice show 2–3x muscle mass increase
   Nature, 1997

2. GDF-8 in Aging and Disease
   Elevated levels linked to sarcopenia and cachexia in humans
   AJP-Endocrinology, 2004

3. Targeting Myostatin Pathway
   Therapeutic inhibition with antibodies or receptor decoys restores muscle strength
   J. Clin. Invest., 2002

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🔗 Related Muscle Research Ingredients

• Follistatin – Myostatin-neutralizing glycoprotein

• ACE-031 – Activin receptor IIB-Fc fusion decoy

• IGF-1 LR3 – Growth-promoting peptide for hypertrophy studies

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⚠️ Research Use Disclaimer

This product is intended exclusively for preclinical and in vitro scientific research. It is not approved for human or animal use. Store under recommended lab conditions.