KPV

KPV | Anti-Inflammatory Tripeptide for Gut, Skin & Immune Modulation Research

Category: Peptides → Anti-Inflammation / Gut Barrier / Skin Repair
Synonyms: Lys-Pro-Val, α-MSH C-terminal fragment
Sequence: Lys-Pro-Val
Molecular Formula: C17H33N5O4
CAS No.: 99963-39-4
Purity: ≥99% (HPLC)

Scientific Overview

KPV is a bioactive tripeptide fragment derived from α-Melanocyte Stimulating Hormone (α-MSH), known for its potent anti-inflammatory, immunomodulatory, and epithelial-repair properties. It functions primarily by inhibiting NF-κB activation, reducing pro-inflammatory cytokine production (e.g., TNF-α, IL-6), and enhancing barrier function in epithelial tissues.

KPV has demonstrated high efficacy in preclinical models of inflammatory bowel disease (IBD), atopic dermatitis, wound healing, and gut-epithelial integrity restoration. Its short size, stability, and non-pigmenting nature make it ideal for both local and systemic inflammation research.

Key Research Applications

• Inflammatory Bowel Disease (IBD) and colitis models
• Gut mucosal integrity and permeability modulation
• Topical therapy and skin inflammation models (eczema, psoriasis)
• Wound healing, re-epithelialization, and fibroblast regulation
• NF-κB, TNF-α, IL-1β signaling pathway studies
• Adjunct peptide for epithelial barrier dysfunction in autoimmune conditions

Highlighted Research Publications

1. Colitis and Gut Inflammation
   KPV suppresses colonic inflammation and improves mucosal healing in IBD models
   Gut, 2003
2. NF-κB Pathway Inhibition
   KPV downregulates nuclear factor kappa B to limit cytokine storm
   Journal of Investigative Dermatology, 2001
3. Topical Application in Skin Models
   Reduces inflammation and accelerates healing in mouse dermatitis models
   Peptides, 2004
4. Mucosal Immune Balance
   KPV promotes epithelial tight junction formation and immune tolerance
   Journal of Leukocyte Biology, 2012

Product Format & Notes

• Form:White lyophilized peptide powder
• Solubility:Soluble in water or PBS
• Storage:–20°C, protected from light and humidity
• Recommended Use:IBD, dermatitis, epithelial inflammation, wound healing research

For Research Use Only

This peptide is supplied strictly for laboratory and academic research. It is not approved for human consumption, clinical use, or diagnostic purposes. Please comply with institutional and national regulations.