Mazdutide

Mazdutide | Dual GLP-1/GCG Receptor Agonist for Obesity & Metabolic Research

Category: Peptides → Metabolic Regulation / Obesity / GLP-1 Agonists
Synonyms: Oxyntomodulin Analog, GLP-1/GCG Dual Agonist, IBI362
Purity: ≥99% (HPLC)

Scientific Overview

Mazdutide is a novel long-acting dual agonist targeting both GLP-1 (glucagon-like peptide-1) and glucagon (GCG) receptors, designed to emulate and enhance the effect of oxyntomodulin, a gut hormone with anorectic and energy-expenditure functions.

Through dual receptor activation, Mazdutide synergistically suppresses appetite, enhances glucose homeostasis, increases basal metabolic rate, and improves hepatic lipid metabolism. It is currently under investigation for its strong therapeutic potential in obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD) research models.

Key Research Applications

• Anti-obesity mechanisms and energy expenditure modeling
• GLP-1 and GCG receptor signaling studies
• Appetite suppression and satiety pathway exploration
• Hepatic lipid metabolism and NAFLD/NASH models
• Glucose regulation and insulin sensitivity enhancement
• Comparison with GLP-1 monoagonists (e.g., Semaglutide, Tirzepatide)

Highlighted Research Publications

1. Weight Loss and Metabolic Improvement
   Mazdutide promotes significant weight reduction and improved lipid profile in primates
   Cell Metabolism, 2022
2. Dual GLP-1/GCG Mechanism
   Dual activation of GLP-1R and GCGR induces both anorectic and thermogenic effects
   Nature Reviews Drug Discovery, 2021
3. Human Clinical Evaluation in Obesity
   Mazdutide (IBI362) demonstrated safety and robust efficacy in Phase 2 obesity trials in China
   The Lancet Diabetes & Endocrinology, 2023
4. NAFLD Model Research
   Dual agonists reduce liver steatosis and improve ALT/AST levels in rodent models
   Journal of Hepatology, 2021

Product Format & Notes

• Form:Lyophilized peptide powder
• Solubility:Soluble in sterile water or dilute acidic buffer
• Storage:–20°C, desiccated and protected from light
• Recommended Use:Obesity and metabolic disorder models, receptor signaling studies

For Research Use Only

This product is intended exclusively for scientific and laboratory research. It is not approved for human use, clinical applications, or diagnostic procedures. Use must comply with institutional and legal research guidelines.