MGF

MGF | Mechano Growth Factor for Muscle Repair & Satellite Cell Activation Research

Category: Peptides → Muscle Growth / Recovery / IGF Splice Variants
Keyphrase: MGF peptide
Purity: ≥99% (HPLC)

🧬 What is MGF (Mechano Growth Factor)?

MGF peptide is a splice variant of the IGF-1 gene (Insulin-like Growth Factor 1), known as IGF-1 Ec. It is naturally expressed in skeletal muscle tissue in response to mechanical overload or damage, such as resistance training or injury. Unlike systemic IGF-1, MGF operates locally, promoting satellite cell activation and initiating muscle fiber regeneration during early recovery phases.

The MGF peptide has gained attention in regenerative medicine and sports science due to its potent myogenic and anabolic activity, making it highly relevant for models of muscle degeneration, sarcopenia, and disuse atrophy.

📌 Product Specifications

• Sequence: YPSSSRAPQT GIVDECCFRS CDLALLETYC ATPAKSE

• Synonyms: IGF-1 Ec, Mechano Growth Factor, IGF splice variant

• Molecular Formula: C121H200N42O39 (varies by analog)

• Molecular Weight: ~2867.2 Da

• Purity: ≥99% (HPLC)

• Keyphrase: MGF peptide

🔬 Scientific Benefits of MGF

• Stimulates satellite cell recruitment and proliferation

• Initiates early muscle repair after damage or resistance exercise

• Distinct from IGF-1 in timing and tissue specificity

• Commonly used in muscle wasting, disuse atrophy, and sarcopenia models

• Enhances myoblast migration and local tissue recovery

📚 Supporting Scientific Literature

1. MGF expression in damaged muscle tissue
   MGF is upregulated post-exercise and essential for local repair
   Journal of Physiology, 2001

2. Satellite cell activation by MGF
   Enhances early stage proliferation of muscle stem cells
   Biochem Biophys Res Commun, 2002

3. MGF decline with age & relevance in sarcopenia
   Reduced MGF linked to aging-related decline in muscle regeneration
   Mechanisms of Ageing and Development, 2004

🔗 Related Products

• IGF-1 LR3 – Long-acting IGF analog

• PEG-MGF – Extended-release version of MGF

• Follistatin – Myostatin inhibitor for muscle hypertrophy

⚠️ For Research Use Only

This compound is intended exclusively for laboratory research. It is not for human or veterinary use, nor for diagnostic or therapeutic purposes. Please follow institutional biosafety guidelines.