Palmitoyl Pentapeptide / Matrixyl

Palmitoyl Pentapeptide | Collagen-Support Peptide for Skin Regeneration & Anti-Aging Research

Category: Skin Health → Anti-Wrinkle / Peptide-Based Dermal Repair
Keyphrase: Palmitoyl Pentapeptide
Purity: ≥99% (HPLC)

🌿 Overview: What is Palmitoyl Pentapeptide?

Palmitoyl Pentapeptide, also known commercially as Matrixyl®, is a lipopeptide composed of a five-amino-acid chain (Lys-Thr-Thr-Lys-Ser) bonded to a palmitic acid molecule. This structure increases lipophilicity and enhances transdermal delivery, making it suitable for use in cosmeceutical and dermatological research.

It works by mimicking natural skin peptides involved in matrix regeneration, thereby stimulating collagen synthesis, elastin production, and fibroblast activity, contributing to smoother and more resilient skin.

🧪 Molecular Details

• Sequence: Pal-Lys-Thr-Thr-Lys-Ser

• Synonyms: Matrixyl®, Pal-KTTKS

• Molecular Formula: C₃₉H₇₅N₇O₁₀

• Molecular Weight: 802.04 g/mol

• Form: Lyophilized powder

• Purity: ≥99% (HPLC)

🔬 Applications in Dermatological Research

• Encourages extracellular matrix regeneration in photoaged skin

• Demonstrates visible wrinkle depth reduction in clinical studies

• Supports skin barrier integrity and moisture retention

• Applied in development of topical peptides, serums, and microneedling formulations

📚 Key Literature

1. Stimulation of Collagen Expression by Matrixyl
   Int J Cosmetic Sci, 2005

2. Clinical Evidence of Anti-Wrinkle Efficacy
   J Cosmetic Dermatology, 2004

3. Topical Peptide Delivery Enhancement
   Skin Pharmacol Physiol, 2012

🔗 Related Skin Science Compounds

• Snap-8 Peptide

• Alpha-Arbutin Peptides

• Niacinamide-Peptide Complex

⚠️ For Research Use Only

This ingredient is for laboratory, formulation, and in vitro testing only. Not for therapeutic or direct consumer use.