Sirolimus / Rapamycin

Field Name	Example Value
Product Name	Sirolimus 100mg
Product Code	SIR-HK-01-30557
Product Type	Small Molecule
Category	Raw Materials / Anti-aging / Immunoregulation
Manufacturer	BLUEBIOTECH
Appearance	White to off-white crystalline powder
Dosage / Units	100mg (packaged by weight)
Purity	≥ 99% HPLC
Quantity Options	100mg / 500mg / 1g
Storage	Store at 2–8°C in a dry place; protect from light
Shelf Life	12 months unopened
Packaging	Sealed foil pouch or HDPE container
Manufacturer Origin	USA
Use Classification	RUO – Research Use Only (Not for human therapeutic use)
Tags	sirolimus, rapamycin, mTOR inhibitor, autophagy, longevity, immune modulation, BLUEBIOTECH

⚠️This product is labeled for Research Use Only (RUO). Not for human or veterinary therapeutic use.
See RUO Declaration for more info.

Sirolimus (Rapamycin) | mTOR Inhibitor for Longevity, Immunomodulation & Regenerative Research

Category: Small Molecules → Anti-Aging / Immunology / Cell Signaling
Keyphrase: Sirolimus (Rapamycin)
Purity: ≥99% (HPLC or LC-MS validated)

🔬 What is Sirolimus (Rapamycin)?

Sirolimus, also known as Rapamycin, is a macrolide compound originally derived from Streptomyces hygroscopicus. It is a highly selective mTOR (mechanistic Target of Rapamycin) pathway inhibitor, widely studied for its roles in cellular senescence control, immune response regulation, and lifespan extension.

Unlike general immunosuppressants, Sirolimus specifically inhibits mTORC1, a key regulatory complex involved in autophagy, protein synthesis, stem cell maintenance, and metabolic homeostasis—making it a cornerstone compound in anti-aging and regenerative research.

🧪 Molecular Profile & Properties

Synonyms: Rapamycin, AY-22989, Sirolimus
Molecular Formula: C₅₁H₇₉NO₁₃
Molecular Weight: 914.17 g/mol
Form: Lyophilized powder or DMSO solution
Purity: ≥99% (HPLC)
Keyphrase: Sirolimus (Rapamycin)

🧬 Research Applications of Sirolimus

Anti-Aging & Longevity Studies:
Extends lifespan in mice and invertebrates by downregulating age-associated mTOR activity.
Immune Modulation & Transplant Models:
Used to prevent organ rejection; enhances Treg cell activity while suppressing effector T-cells.
Autophagy Induction & Neuroprotection:
Promotes autophagy, useful in neurodegenerative models including Alzheimer’s and Parkinson’s disease.
Cancer & Tumor Biology:
Blocks tumor progression in several cancers by disrupting protein synthesis and angiogenesis.
Stem Cell & Regenerative Medicine:
Maintains pluripotency and protects hematopoietic stem cells from exhaustion.

📚 Scientific Literature Supporting Sirolimus Research

Rapamycin Extends Lifespan in Mice
First study demonstrating longevity extension with late-life administration
Nature, 2009
mTOR Inhibition in Aging and Disease
Comprehensive review on mTOR’s central role in cellular aging
Cell Metabolism, 2013
Rapamycin and Autophagy Induction in Neurodegeneration
Protective effect in Alzheimer’s disease models
Journal of Neuroscience, 2010

🔗 Related Compounds in Longevity & Cell Signaling Research

SRT-1720 – SIRT1 activator for metabolic regulation
Epithalon – Telomerase-activating peptide for aging studies
Elamipretide (SS-31) – Mitochondrial peptide for cellular rejuvenation

⚠️ For Research Use Only

Sirolimus (Rapamycin) is strictly provided for laboratory-based, in vitro or preclinical research purposes. It is not intended for human use unless under approved clinical protocols.

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⚠️ All compounds are provided strictly for Research Use Only (RUO). BLUEBIOTECH does not endorse or support clinical, therapeutic, or diagnostic use of its products unless under licensed compounder supervision.

Sirolimus / Rapamycin