Snap-8

Snap-8 Peptide | Argireline-Like Peptide for Expression Line & Wrinkle Inhibition Research

Category: Peptides → Skin Health / Cosmetic Science / Anti-Wrinkle
Keyphrase: Snap-8 peptide
Purity: ≥99% (HPLC)

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🧬 What is Snap-8?

Snap-8 peptide (Acetyl Octapeptide-3) is a laboratory-engineered peptide designed to reduce dynamic wrinkles caused by repeated facial expressions. It is a biomimetic analog of the N-terminal domain of SNAP-25, part of the SNARE complex that mediates neuronal exocytosis. By interrupting SNARE formation, it reduces acetylcholine release at neuromuscular junctions, leading to a decrease in facial muscle contractions and expression lines.

Snap-8 is widely regarded as a second-generation alternative to Argireline (Acetyl Hexapeptide-8), offering enhanced efficacy in in vitro wrinkle depth reduction—up to 30% greater in some studies. It is commonly studied in cosmeceutical peptide models focused on non-invasive anti-aging strategies.

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📌 Product Specifications

• Sequence: Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂

• Synonyms: Acetyl Octapeptide-3, SNAP-8, Botox-like peptide

• Molecular Formula: C50H87N15O15

• Molecular Weight: ~1075.3 Da

• Purity: ≥99% (HPLC)

• Form: Lyophilized peptide powder

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🔬 Research Applications & Mechanism

Snap-8’s mechanism centers on neurotransmission modulation, particularly in facial musculature. By partially mimicking the structure of SNAP-25, it competitively inhibits vesicle docking and neurotransmitter release, acting as a functional mimic of botulinum toxins—but without the need for injection. This makes it a highly desirable candidate in peptide-based topical formulations aiming for expression line control.

In research environments, Snap-8 is evaluated for:

• Crow’s feet reduction

• Forehead line smoothing

• Non-invasive neuromodulatory strategies

It is also tested in combination with GHK-Cu, Palmitoyl Pentapeptide, and Matrixyl analogs for synergistic skin rejuvenation effects.

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📚 Key Scientific Literature

1. SNAP-8 modulates the SNARE complex and softens muscle tension.
   Int. J. Cosmetic Sci.

2. Improves wrinkle depth compared to Argireline.
   J. Pept. Sci.

3. Delivery system research supports long-term peptide stability in topical applications.
   Molecules, 2021

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🔗 Related Research Ingredients

• GHK-Cu – Copper peptide for skin repair

• Palmitoyl Pentapeptide – Collagen-stimulating cosmetic peptide

• Melanotan-1 – Skin tone & photoprotection peptide

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⚠️ For Research Use Only

This product is for laboratory research only. Not for use in humans or for cosmetic application. Store at –20°C in a dry, light-protected environment.