Thymalin

Thymalin | Thymic Peptide Complex for Immunomodulation & Geroprotection Research

Category: Peptides → Immune Regulation / Hematopoiesis / Anti-Aging
CAS No.: 63958-90-7
Molecular Formula: C₃₈H₆₂N₁₂O₁₄ (approx., varies by fraction)
Synonyms: Thymus Extract, Thymus Peptide Complex, Synthetic Thymalin
Purity: ≥99% (HPLC)

Scientific Overview

Thymalin is a synthetic polypeptide complex originally derived from the thymus gland, representing short peptides that mimic the natural thymic factors involved in immune regulation. It has been extensively studied in Russia and Eastern Europe for its ability to restore T-cell function, modulate hematopoiesis, and slow age-related degenerative changes.

Thymalin exerts its action through epigenetic regulation of gene expression, particularly affecting genes involved in cell cycle control, immune surveillance, and inflammation suppression. It is also implicated in telomere protection, stem cell activation, and DNA repair signaling, making it a valuable tool in gerontology and immunosenescence research.

Key Research Applications

• Immunomodulation and T-lymphocyte maturation studies
• Restoration of thymic function in aged models
• Hematopoiesis and stem cell activation assays
• Geroprotective research targeting inflammaging and immunosenescence
• Supportive peptide in chemotherapy-induced immune suppression models
• Investigation of DNA repair, telomere integrity, and oxidative stress

Highlighted Research Publications

1. Immune Function Restoration
   Thymalin restores T-cell immunity and improves lymphopoiesis in aged animals
   Bulletin of Experimental Biology and Medicine, 2000
2. Geroprotective Properties
   Long-term use of thymic peptides prolongs lifespan and reduces mortality in elderly patients
   Neuro Endocrinol Lett, 2002
3. Epigenetic and Stem Cell Effects
   Thymalin influences gene expression linked to proliferation and immune regulation
   Biochemistry (Moscow), 2003
4. Antitumor and Cytoprotective Activity
   Thymalin reduces inflammation and supports hematologic recovery post-chemotherapy
   Experimental Oncology, 2011

Product Format & Notes

• Form:White lyophilized peptide powder
• Solubility:Soluble in water or phosphate buffer
• Storage:–20°C, avoid light and moisture exposure
• Suggested Use:Immunology models, gerontology research, hematopoietic studies

For Research Use Only

This compound is intended solely for scientific research use. It is not approved for human use, therapeutic intervention, or diagnostic purposes. Use in compliance with institutional and regulatory guidelines is required.